| Outer membrane efflux protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | OEP | ||||||||
| Pfam | PF02321 | ||||||||
| InterPro | IPR003423 | ||||||||
| SCOP | 1ek9 | ||||||||
| TCDB | 2.A.6 | ||||||||
| OPM family | 34 | ||||||||
| OPM protein | 1yc9 | ||||||||
|
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Outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.
Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.